Chronic Myeloid Leukaemia
نویسندگان
چکیده
Chronic myeloid leukaemia (CML) is a malignant myeloproliferative disorder of haemopoietic stem cells, giving rise to abnormally elevated numbers of myeloid cells in peripheral blood and myeloid hyperplasia in bone marrow. Uncontrolled production of myeloid precursors results in increased levels of maturing granulocytes, mainly neutrophils but also eosinophils and basophils. Elevated numbers of erythoid cells and platelets are also found.
منابع مشابه
Detection of abl/bcr Fusion Gene in Patients Affected by Chronic Myeloid Leukaemia by Dual-Colour Interphase Fluorescence in situ Hybridisation
Conventional cytogenetic is the standard technique for detection of Philadelphia (Ph) chromosome in chronic myeloid leukemia (CML). Evaluation of abelson murine leukemia/breakpoint cluster region (abl/bcr) fusion using dual-colour fluorescence in situ hybridization (D-FISH) is an alternative approach allowing rapid and reliable detection of the disease. We employed the technique of interphase D...
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